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e-mail: jflot@ulb.ac.be











Research interests



Molecular approaches to species delimitation - Molecular systematics - Genome assembly - Experimental evolution - Genome evolution - Bioinformatics





Selected publications



For a complete list see Google Scholar or http://seqphase.mpg.de/publications/

Flot J-F (2010) SeqPHASE: a web tool for interconverting phase input/output files and fasta sequence alignments. Molecular Ecology Resources 10, 162-166.

This article presents a computer programme facilitating the inference of haplotype sequences from genotypes in a population of individuals.

Flot J-F, Couloux A, Tillier S (2010) Haplowebs as a graphical tool for delimiting species: a revival of Doyle's "field for recombination" approach and its application to the coral genus Pocillopora in Clipperton. BMC Evolutionary Biology 10, 372.

In this article I introduce a new graphical approach to species delimitation using haplowebs, i.e. haplotype networks on which sequences found co-occurring in heterozygous individuals are connected with curves. This approach bases itself on allele sharing to delineate species and therefore does not require species to be monophyletic (hence it is not affected by incomplete lineage sorting).

Flot J-F, Blanchot J, Charpy L, et al. (2011) Incongruence between morphotypes and genetically delimited species in the coral genus Stylophora: phenotypic plasticity, morphological convergence, morphological stasis or interspecific hybridization? BMC Ecology 11, 22.

This article presents another type of haploweb (tree-based instead of network-based) and its application to species delimitation in corals.

Flot J-F, Hespeels B, Li X, et al. (2013) Genomic evidence for ameiotic evolution in the bdelloid rotifer Adineta vaga. Nature 500, 453-457.

Available biological and paleontological data suggest that bdelloid rotifers have been reproducing in a purely asexual fashion for tens of million years, but this hypothesis remains controversial. This article presents the highly unusual genome structure of bdelloids and interprets it as the result of ameiotic evolution.

Flot J-F, Bauermeister J, Brad T, et al. (2014) Niphargus-Thiothrix associations may be widespread in sulphidic groundwater ecosystems: evidence from southeastern Romania. Molecular Ecology 23, 1405-1417.

This article uses haplowebs and phylogenetic trees to delineate amphipod species inhabiting the underground of the Mangalia region of Romania (including Movile Cave, a rare example of chemoautotrophic ecosystem analogous to the those found on oceanic ridges) and analyses their symbioses with sulphur-oxidizing bacteria of the genus Thiothrix.

Flot J-F (2015) Species delimitations’s coming of age. Systematic Biology 64, 897-899.

The article introduces a special issue of Systematic Biology focused on new molecular approaches to species delimitation.

Flot J-F, Marie-Nelly H, Koszul R (2015) Contact genomics: scaffolding and phasing (meta)genomes using chromosome 3D physical signatures. FEBS Letters 589, 2966-2974.

This article reviews recent the advances and perspectives offered by 3C (chromosome conformation capture) in the field of genome sequencing.

Debortoli N, Li X, Eyres I, et al. (2016) Genetic exchange among bdelloid rotifers is more likely due to horizontal gene transfer than to meiotic sex. Current Biology 26, 723-732.

This article (whose first author is a PhD student I co-supervise in Namur) reports that bdelloid rotifers of the genus Adineta exchange DNA both within and between species. As signatures of exchanges are scattered among genomic regions evolving asexually, these exchanges are better explained by horizontal gene transfers than by meiotic sex.

Schwager EE, Sharma PP, Clarke T et al. (2017) The house spider genome reveals an ancient whole-genome duplication during arachnid evolution. BMC Biology 15:62

This article demonstrates that spiders and scorpions probably share an ancient, ancestral whole-genome duplication.





Team



Lab technician

Esra Kaymak (2015-2016, shared with the group of Olivier Hardy)

Sandra Cervantes Arango (2017-present)


Postdoctoral researchers

Eulalia Banguera Hinestroza (2016-present)

Antoine Limasset (2017-present)


PhD students

EEG group in September 2017

(absent: Stephen Bergacker, Emilie Berns, Nicolas Debortoli, Alessandro Derzelle, Grégory Philippart, Ana Rodriguez, Fabio Stoch, Dieter Weber)


Nicolas Debortoli (2012-present, co-supervised with Karine Van Doninck)

Alessandro Derzelle (2014-present, co-supervised with Karine Van Doninck)

Fabio Stoch (2016-present)

Dieter Weber (2016-present)

EEG group in September 2016

(absent: Stephen Bergacker, Nicolas Debortoli,
Alessandro Derzelle)


Catalina Ramírez Portilla (2017-present, co-supervised with Thomas Wilke)

Ana Rodriguez (2017-present, co-supervised with Isabelle George)

Yann Spöri (2017-present, co-supervised with Simon Dellicour)


MSc students

Yann Spöri (2017)

Emilie Berns (2017-present, co-supervised with Frédéric Sinniger)

Martin Collette (2017-present)

Grégory Philippart (2017-present, co-supervised with Philippe Grosjean)

Giula Puntin (2017-present, co-supervised with David M. Baker)


Interns

Stephen Bergacker (2016-present)

Antoine Limasset (2016, 3 months)

Catalina Ramírez Portilla (2016, 1 month)

Yann Spöri (2016, 3 months)

René Desneux (2017, 1 month)







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